The following are symptoms you will experience if you decide to overdose on Tramadol: difficulty breathing, change in consciousness, reduced muscle tone, severe fatigue, shortness of breath, unusual tiredness, and irregular heartbeat. As you can see, a lot of those symptoms can be life-threatening and even lead to other health issues. Again it needs to be noted that experiencing some of these symptoms does not mean you are overdosing, but it does mean you should go see your doctor for a further evaluation.